Smita Krishnaswamy

Smita Krishnaswamy is an associate professor in genetics and computer science. Krishnaswamy is affiliated with the applied math program, computational biology program, Yale Center for Biomedical Data Science, and Yale Cancer Center. Krishnaswamy’s research focuses on the development of machine learning techniques to analyze high-dimensional, high-throughput biomedical data. Her concentration is on unsupervised machine learning methods, specifically manifold learning, and deep learning techniques for detecting structure and patterns in data. She has developed algorithms for non-linear dimensionality reduction and visualization, learning data geometry, denoising, imputation, inference of multi-granular structure, and inference of feature networks from big data. The Krishnaswamy lab has applied these techniques to many data types such as single cell RNA-sequencing, mass cytometry, electronic health record, and connectomic data from a variety of systems. Specific application areas include immunology, immunotherapy, cancer, neuroscience, developmental biology, and health outcomes.

Krishnaswamy has a PhD in computer science and engineering from the University of Michigan.